Endoplasmicreticulumstress相关论文
目的:探讨梓醇对非酒精性脂肪肝病(non-alcoholic fatty liver disease, NAFLD)治疗及降脂机制。方法:高脂饮食喂养ICR小鼠8周以建......
Nonalcoholic fatty liver disease (NAFLD) can cause serious liver damage.Early diagnosis and effective treatment of NAFLD......
Zonisamide alleviates cardiac hypertrophy in rats by increasing Hrd1 expression and inhibiting endop
Antiepileptic drug zonisamide has been shown to be curative for Parkinson\'s disease (PD) through increasing HMG-CoA r......
内质网应激(endoplasmic reticulum stress,ERS)与帕金森病(Parkinson\'s disease,PD)发展进程密切相关.Apelin是已被证实具有明......
Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-
Objective:To test the hypothesis that the inhibition of endoplasmic reticulum (ER) stress-induced apoptosis in oxidized ......
Unfolded protein response (UPR) is an adaptive reaction for cells to reduce endoplasmic reticulum (ER) stress.In many ty......
N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reti
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HSP110 functions to protect cells tissues and organs from noxious conditions.Vasectomy induces apoptosis in the testis;h......
The Role of Endoplasmic Reticulum Stress and Insulin Resistance in the Occurrence of Goose Fatty Liv
Introduction In mammals,insulin resistance (IR) is essential to the development of non-alcoholic fatty liverdisease (NAF......
Intracellular Ca2+ release through oxidation of ryanodine receptors contributes to Selenoprotein W-m
Ca2+ leak induces the mitochondria or sarco/endoplasmic reticulum (SR/ER)related cell death.In the present study ,we exa......
Dexamethasone induces osteoblasts apoptosis by Ca2+/CamKⅡ pathways mediated endoplasmic reticulum st
Aim:Dexamethasone induced osteoblasts apoptosis is a major characteristic in the pathogenesis of glucocorticoid-induced ......
Picosecond pulsed electric fields induce apoptosis in HeLa cells via the endoplasmic reticulum stres
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Caveolin-1 deficiency causes pulmonary fibrosis alters energy metabolism and induces endoplasmic ret
目的 Caveolin-1 (Cav-1), a major structural protein of caveolae, is involved in many physiological and pathophysiologica......
High Expression of Valosin-Containing Protein Predicts Poor Clinical Outcome in Locally Advanced Eso
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Cerebral dopamine neurotrophic factor(CDNF)alleviates endoplasmic reticulum stress-induced cell dama
Background Astrocyte damage and the disorders of cytokine secretion induced by endoplasmic reticulum stress(ERS)are cruc......
Objective Doxorubicin(DOX)is a chemotherapy medication used to treat various cancers.However,cardiotoxic side effects li......
The relationshio between nuclear factor-kappa B signaling pathway and intervertebral disc degenerati
Background: Although recent studies indicate that nuclear factor-kappa B(NF-κB)signaling pathway was activated in IDD,t......
Endoplasmic reticulum stress contributes to acetylcholine receptor degradation by promoting endocyto
INTRODUCTION AND OBJECTIVES After binding by acetylcholine released from a motor neuron, a nicotinic acetylcholine recep......
Aims:Nogo-B plays crucial roles in vascular remodeling.However,its roles in cardiac remodeling remain unclear.The aim of......
Grape Seed Proanthocyanidin Protects Liver against Ischemia/Reperfusion Injury by Attenuating Endopl
Background: Liver ischemia/reperfusion (I/R) injury induces the occurence of endoplasmic reticulum (ER) stress.The immod......
Endoplasmic reticulum oxidoreductin 1α mediates hepatic endoplasmic reticulum stress in homocysteine
Endoplasmic reticulum (ER) stress is emerging as an important modulator of different pathological process and as a mecha......
Chronic restraint stress promotes learning and memory Impairments due to enhance oxidative stress in
Aim: Chronic stress is implicated in many types of neurodegenerative diseases such as Alzheimers disease (AD).The presen......
Aim: Endoplasmic reticulum stress (ER stress) is known to play a vital role in mediating ischemic reperfusion damage in ......
4-phenylbutyrate protects against renal interstitial fibrosis induced by unilateral ureteral obstruc
Objective: Renal tubulointerstitial fibrosis is the common and final pathologic change of kidney in end-stage renal dise......
Cardioprotection of H2S against ischemia reperfusion injury through inhibiting endoplasmic reticulum
To investigate whether hydrogen sulfide (H2S) protect the heart against myocardial ischemia/reperfusion (I/R) injury by ......
Microcarrier as pulmonary drug delivery system for treatment of pulmonary fibrosis induced by paraqu
It has been shown that endoplasmic reticulum stress (ERS) is involved in the pulmonary fibrosis.Fluorofenidone (AKF) is ......
Study on the combination effects of siPERK and siATF4 on cell growth and apoptosis in cartilage deve
We previously report that BMP2 mediates mild ER stress.The mammalian unfolded protein response (UPR) protects the cell a......
Reactive oxygen species (ROS) are crucial in the pathogenesis of diabetic nephropathy (DN).X-box binding protein 1(XBP1)......
LASS2 enhances the chemosensitivity of bladder cancer by inhibiting endoplasmic reticulum pathway-me
目的 The purpose of the present study was to elucidate the relationships among LASS2,autophagy and bladder cancer chemos......
Adiponectin protects the kidney against chronic intermittent hypoxia-induced injury through inhibiti
Purpose The current study was carried out to assess the ef-fects of chronic intermittent hypoxia (CIH) on the kidney, th......
Licochalcone A triggers autophagy by activation of endoplasmic reticulum stress in non-small cell lu
Aim Licochalcone A (LCA), a flavonoid isolated from the famous Chinese medicinal herb licorice, presents obvious anti-pr......
Ghrelin Protects H9c2 Cardiomyocytes from Angiotensin Ⅱ-induced Apoptosis Through the Endoplasmic Re
Objective Ghrelin, a gastric hormone, exerts cardio-protective function by increasing myocardial contractility and vasod......
3beta-hydroxysteroid-delta24 reductase protects neuronal cells against apoptosis induced by endoplas
3beta-hydroxysteroid-delta24 reductase (DHCR24) is a multifunctional enzyme with anti-apoptotic and cholesterol-synthesi......
Objective Various highly conserved genes and proteins are expressed during embryonic development.Neuronal Development-As......
Novel structure compounds (5a-5g and 6a-6c) containing indole-2-one and chalcone moiety were designed and synthesized ba......
Hyperhomocysteinemia promotes insulin resistance by inducing endoplasmic reticulum stress in adipose
Aims: Type 2 diabetes is a chronic inflammatory metabolic disease, the key point being insulin resistance.Endoplasmic re......
Acetyl shikonin inhibits proliferation and induces apoptosis by triggering endoplasmic reticulum str
Acetyl shikonin(AS),one of active components of Lithospermum erythrorhizon Sieb.et Zucc,a well-known Chinese traditional......
Reactive oxygen species and Ca2+ signaling during myocardial ischemia/reperfusion injury and protect
Myocardial injury following ischemia/reperfusion (I/R) is a common clinical scenario in patients suffering from ischemic......
6-Shogaol Induces Apoptosis in Human Hepatocellular Carcinoma Cells through Endoplasmic Reticulum St
6-Shogaol is an active compound isolated from Ginger (Zingiber officinale Rosc).In this work,we demonstrated that 6-shog......
Endoplasmic reticulum stress ATF4-mediated cyclooxygenase-2 induction regulates lupus nephritis-indu
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Cardioprotective Effects of Gypenoside XVII on Endoplasmic Reticulum Stress-Mitochondrial Damage Cro
Aim: Effective strategies have been developed to prevent or improve recovery from myocardial ischemia and reperfusion(I/......
Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associa
Objective: To verify that PRP-Exos prevent apoptosis induced by glucocorticoid-associated ER stress in rat ONFH via the ......
ER stress-mediated renal fibrosis is attenuated by chemical chaperon 4-phenylbutyrate in vitro and i
Renal tubule interstitial fibrosis is the common and final pathologic change of kidney in end-stage renal disease.Endopl......
Severe Endoplasmic Reticulum Stress Response Predicts the Occurrence of Hepatitis B Virus-related Ac
Background Although endoplasmic reticulum(ER)stress is critical in various liver diseases,its role in acute-on-chronic l......
Endoplasmic Reticulum Stress Induced by Tunicamycin and Thapsigargin Protects against Transient Isch
Transient cerebral ischemia leads to the endoplasmic reticulum(ER)stress.However,the contributions of ER stress to cereb......
Based on Endoplasmic reticulum stress and inflammation to study cardiac remodeling and the effect of
The endoplasmic reticulum, an important intracellular organelle of eukaryocyte, is the factory for folding and maturatio......
Exogenous basic fibroblast growth factor inhibits endoplasmic reticulum stress induced apoptosis and
OBJECTIVE To investigate the mechanism of endoplasmic reticulum stress (ERS)-induced apoptosis as well as the protective......
Role of Inhibition of Mitochondrial Permeability Transition Pore Opening in Protecting the Damage of
Aim: Sepsis or septic shock is a severe complication after severe trauma or infection, its morbidity and mortality were ......
Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomyc
Several reports indicate that melatonin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rodent animals.Neverthe......
